01-P002 Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation
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چکیده
منابع مشابه
01-P002 Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation
Nuage, a well conserved perinuclear organelle found in germline cells, is thought to mediate the repression of retroelements in Drosophila melanogaster by regulating the production of Piwiinteracting RNAs (piRNAs). Here, we present evidence that the nuage/piRNA pathway components can be found in cytoplasmic foci that also contain retroelement transcripts, anti-sense piRNAs and proteins involved...
متن کاملCorrection: Highly Dynamic and Sex-Specific Expression of microRNAs During Early ES Cell Differentiation
[This corrects the article DOI: 10.1371/journal.pgen.1000620.].
متن کاملHighly Dynamic and Sex-Specific Expression of microRNAs During Early ES Cell Differentiation
Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of the mammalian blastocyst. Cellular differentiation entails loss of pluripotency and gain of lineage-specific characteristics. However, the molecular controls that govern the differentiation process remain poorly understood. We have characterized small RNA expression profiles in differentiating ES cells as a mode...
متن کاملSpecific microRNAs modulate ES cell-derived neurogenesis
MicroRNAs (miRNAs) are recently discovered small non-coding transcripts with a broad spectrum of functions described mostly in invertebrates. As post-transcriptional regulators of gene expression, miRNAs trigger target mRNA degradation or translational repression. While hundreds of miRNAs have been cloned from a variety of mammalian tissues and cells, and multiple mRNA targets have been predict...
متن کامل01-P020 MicroRNA regulation of ES cell differentiation
Hox genes are essential transcription factors that establish segmental identity on the head–tail axis of all animals. Proper regulation of Hox gene expression and function is in part accomplished through the actions of a multitude of noncoding RNAs. One important class of noncoding RNA, the micro-RNAs (miRNAs), regulates gene activity through translational repression. The miR-10 family is highl...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.003